在2型糖尿病中,带带状回膜的结构和功能连接性改变模式在2型糖尿病中
Dongsheng Zhang1, Yang Huang1, Shasha Liu1
1Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, China.
前带皮质 (ACC) 和后皮质 (RSC) 中的功能性大脑连接性变化在2型糖尿病 (T2DM) 患者出现结构变化之前,可能表明早期认知障碍.
科学领域:
- 神经成像是一种神经成像.
- 内分泌学 在内分泌学.
- 认知神经科学 认知神经科学
背景情况:
- 2型糖尿病 (T2DM) 与认知障碍有关.
- 早期发现T2DM认知衰退对于及时干预至关重要.
- 在T2DM相关的认知障碍中,带带回的作用需要进一步阐明.
研究的目的:
- 调查T2DM患者早期认知障碍中带状回环的结构和功能变化.
- 为了比较T2DM患者和健康对照者 (HCs) 之间的大脑结构和功能连接 (FC).
- 探索带状回形变化与认知/临床变量之间的关系.
主要方法:
- 对56名T2DM患者和60名HC患者进行了神经心理评估和休息状态功能性MRI (rs-fMRI).
- 分析了带状回形子区域的皮层厚度和FC.
- 相关性分析检查了大脑测量和临床/认知数据之间的关系.
主要成果:
- 在T2DM患者和HC患者之间没有发现 cingulate gyrus皮质厚度的显著差异.
- T2DM患者表现出改变的FC:在前性ACC (pACC) 和海马之间降低,在pACC和侧面前额皮质 (LPFC) /前中心之间增加,并在后皮质 (RSC) 和大脑小叶Crus I之间降低.
- 改变的pACC连接性显示出与认知功能有负相关性.
结论:
- 在T2DM患者中,pACC和RSC的功能障碍连接发生在可观察到的结构变化之前.
- 改变了pACC与海马和LPFC的连接性可能代表了对记忆缺陷的补偿机制.
- 这些发现提供了对T2DM相关认知障碍和潜在治疗点的见解.
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