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在HCC患者中对CLOCK,BMAL1,CRY1,CRY2,PER1,PER2,PER3和NPAS2蛋白质的基因变化的生物信息分析

Durmus Ayan1,2, Ak Cagatay3

  • 1Department of Medical Biochemistry, Nigde Training and Research Hospital, Nigde, Turkiye.

Hepatology forum
|October 12, 2023
PubMed
概括

研究肝癌 (HCC) 中的昼夜节律基因揭示了突变和改变表达. 特定的基因变化,如PER1和CRY2,与患者的存活率相关,提供潜在的治疗点.

关键词:
在CRY2中使用CRY2.循环节律基因是循环节律的基因.在NPAS2中,NAS2是NPAS2的第二个部分.在 PER1 中, PER1 是 PER1 的代名词.在 PER2 中, PER2 是 PER2 的代码.肝细胞癌是一种肝细胞癌.

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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