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在慢性斑块性牛皮症中介质素水平和非酒精性脂肪肝疾病:分析病例控制研究
Vidya Yadav1, Vibhu Mendiratta1, Aparna Agrawal2
1From the Department of Dermatology and STD, Lady Hardinge Medical College and Sucheta Kriplani Hospital, New Delhi, India.
Indian journal of dermatology
|October 12, 2023
概括
牛皮患者患有与炎症相关的非酒精性脂肪性肝病 (NAFLD) 的患病率更高. 建议对患有牛皮的牛皮患者进行NAFLD早期查,这些患者有肥胖和胰岛素抵抗等危险因素.
科学领域:
- 皮肤病学 皮肤病学
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病.
- 牛皮的炎症媒介不平衡与胰岛素抵抗,代谢综合征和非酒精性脂肪肝疾病 (NAFLD) 有关.
研究的目的:
- 为了确定与对照组相比,慢性斑块性牛皮患者中NAFLD的发生频率.
- 为了研究牛皮患者和对照组的介质蛋白水平.
- 探索牛皮严重程度,代谢因素和NAFLD之间的关联.
主要方法:
- 招募了50例慢性斑块性牛皮病例和30例对照.
- 测量的BMI,腰围,脂质概况,禁食血糖,食后血糖和血清胰岛素.
- 评估了中间蛋白水平 (IL1-β,IL6,TNF-α),肝功能测试,并使用了超声波和FibroScan进行NAFLD和纤维化评估.
主要成果:
- 在牛皮病例中,NAFLD的发生频率明显高于对照组 (6.6%),高于牛皮病例 (56.0%).
- 牛皮患者表现出腰围升高,血清胰岛素,脂质特征异常,脂肪肝和肝纤维化率较高.
- 牛皮患者的NAFLD与更长的疾病持续时间,更高的BMI,更大的腰围,更大的身体表面积参与和脂质失调有关.
结论:
- 牛皮患者的高素水平表明,炎症在疾病发病过程中起着作用.
- 牛皮患者中NAFLD患病率增加凸显了该疾病的全身炎症性质.
- 建议在患有牛皮的牛皮患者进行NAFLD查,这些患者有肥胖,胰岛素耐药性和更长的疾病持续时间等危险因素.
关键词:
体重指数 (BMI) 是指身体质量指数.身体表面积 (BSA) 是指身体的表面积.FBS (禁食血糖) 是指快餐时的血糖.在IL-6的研究中,IL-6被认为是IL-6的基因.在IL1-β中,它是IL1-β.肝功能测试 (LFT) 是一种肝功能测试.非酒精性脂肪性肝病 (NAFLD) 是一种非酒精性脂肪性肝病.PASI (牛皮地区严重程度指数)这是一种TNF-α (中白蛋白) 基因.在 Th-1-1 中.慢性斑块性牛皮病 慢性斑块性牛皮病脱脂血症是什么情况脂肪肝是一种脂肪肝.纤维扫描 (Fibroscan) 是一种扫描方式.肝脏纤维化 肝脏纤维化血清胰岛素水平 血清胰岛素水平超氨基酸炎的发生腰围 (WC) 是指腰围的周长.相关概念视频
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