在白病患者中,提二硫化物恒温,缺血修饰的白蛋白,微量元素和维生素
Esra Firat Oğuz1, Yildiz Hayran2, Çiğdem Yücel3
1From the Department of Clinical Biochemistry, Ankara City Hospital, Ankara, Turkey.
Indian journal of dermatology
|October 12, 2023
概括
Vitiligo 患者表现出较低的硫醇水平和较高的水平,表明氧化应激增加. 这些发现突出了氧化失衡在这种脱色皮肤状况中的作用.
科学领域:
- 皮肤病学 皮肤病学
- 生物化学 生物化学
- 临床医学 临床医学
背景情况:
- Vitiligo 是一种多因素性皮肤疾病,其特点是黑色素细胞的丧失和皮肤色素的剥离.
- 这种情况导致受影响区域的皮肤颜料明显减少.
研究的目的:
- 在白病患者中研究硫酸乙醇稳定,缺血修饰性白蛋白 (IMA) 和铜,,,维生素A和维生素C的水平.
- 探索这些生物标志物与白风中氧化应激状态之间的关系.
主要方法:
- 该研究包括83名白风患者和72名健康对照.
- 原子吸收光谱,高性能液态色谱和色度测量方法被用来测量各种生物标志物.
- 分析了原生/总醇,缺血改性白蛋白,铜,,,维生素A和维生素E的血清水平.
主要成果:
- Vitiligo 患者的血清原生和总硫醇水平显著降低 (P < 0.001).
- 与对照组相比,白风患者的含量显著更高 (P = 0.004).
- 铜,,维生素A或维生素E水平在两组之间没有显著差异.
结论:
- Vitiligo 患者表现出增加的氧化应激状态,其证据是改变的硫化-硫化平衡.
- 白风的严重程度与身体中氧化应激增加有关.
- 这些发现强调了评估抗氧化剂-氧化剂系统,微量元素和维生素在白风管理中的重要性.
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