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CD38通过NAD代谢调节卵巢功能和生育能力
Rosalba Perrone1, Prasanna Vadhana Ashok Kumaar1, Lauren Haky1,2
1Buck Institute for Research on Aging, Novato, CA, USA.
iScience
|October 12, 2023
概括
CD38是一种消耗NAD+的酶,在哺乳动物卵巢中随着年龄的增长而增加. 在年轻小鼠中去除CD38可以提高卵巢NAD+和生育能力,从而保持卵巢储备.
科学领域:
- 生殖生物学 生殖生物学
- 衰老的研究研究.
- 生物化学 生物化学
背景情况:
- 哺乳动物雌性生殖寿命有限,比总体预期寿命短.
- 卵巢的NAD+水平随着年龄的增长而下降,但根本的机制尚不清楚.
- NAD+对细胞能量和功能至关重要,其下降与衰老有关.
研究的目的:
- 研究CD38在卵巢NAD+代谢中的作用及其对女性生殖寿命的影响.
- 为了确定CD38表达如何随着生殖年龄的变化而变化.
- 评估CD38缺乏对卵巢储备和生育能力的影响.
主要方法:
- 在不同生殖年龄的卵巢组织中对CD38的表达分析.
- 对缺乏CD38的小鼠进行研究,以评估卵巢NAD+水平,原始卵泡数量和生育能力.
- 在CD38缺乏和野生型小鼠的早期发育期间评估卵泡形成动态.
主要成果:
- CD38在卵巢的卵泡外空间表达,主要在免疫细胞中,其水平随着生殖年龄的增加而上升.
- 缺少CD38的小鼠显示卵巢NAD+水平增加和更大的原始卵泡池.
- 由于长时间的毛囊形成,CD38缺乏导致生殖年轻小鼠的生育能力提高.
- 随着年龄的增长,CD38损失的有益影响会减弱.
结论:
- CD38在调节卵巢NAD+代谢方面发挥着重要作用.
- CD38影响了卵巢储备的建立,影响了女性的生殖寿命.
- 向CD38可能提供调节卵巢储备和生殖衰老的策略,尽管需要考虑依赖年龄的影响.
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