通过向扩散,缺氧和炎症,对大鼠埃里希癌的埃奇纳科赛德的影响
Afnan Alshehri1, Aeshah Albuhayri2, May Alanazi2
1PharmD Program, Faculty of Pharmacy, University of Tabuk, Tabuk, SAU.
Cureus
|October 12, 2023
概括
乙可胺在患有埃里希固体癌 (ESC) 的老鼠中表现出显著的抗瘤作用,增加了生存时间并减少了瘤大小. 这种天然化合物还通过减少炎症和抑制癌细胞增殖和分化来改善肌肉结构.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 埃里希固体癌 (ESC) 是一种用于癌症研究的攻击性小鼠乳腺腺癌模型.
- 乙可化物是一种天然的甲基可化物,具有已知的抗炎和抗氧化特性.
研究的目的:
- 在埃里希固体癌症 (ESC) 的老鼠模型中研究埃希纳科赛德的抗癌潜力.
- 为了分析 echinacoside 对瘤细胞增殖,分化,运动和炎症的影响.
主要方法:
- 给老鼠注射ESC细胞,14天后,每天给老鼠注射30毫克/公斤长达3周的乙化物 (30毫克/公斤).
- 使用电子显微镜分析瘤组织,并评估关键因素 (PI3K,mTOR,HIF-1α,cyclin D1,CDK2,TNF-α,NFκB) 的基因/蛋白质表达.
主要成果:
- 乙化治疗显著增加了平均存活时间,从27天增加到48天.
- 瘤体积和体重减少,观察到瘤组织结构的改善和减少缩迹象.
- 乙化物抑制了PI3K,mTOR,HIF-1α,cyclin D1,CDK2,TNF-α和NFκB的表达.
结论:
- 乙化物在老鼠中对ESC表现出显著的抗瘤特性.
- 该化合物改善缺氧,减少炎症,并抑制癌细胞增殖和分化途径.
- 乙化物治疗改善了肌肉结构,并增加了瘤携带大鼠的生存时间.
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