老年中国妇女口腔微生物组和缺血性中风风险
Cong Wang1, Yaohua Yang1,2, Qiuyin Cai1
1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Journal of oral microbiology
|October 12, 2023
概括
口腔微生物组可能会影响缺血性中风风险. 特定的口腔细菌与中风风险降低有关,这表明口腔健康和脑血管疾病之间存在潜在联系.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 卒中是全球残疾的主要原因之一.
- 牙周炎与中风有关.
- 口腔微生物群和中风风险之间的关系尚未得到充分理解.
研究的目的:
- 调查口腔微生物组与缺血性中风风险之间的关联.
主要方法:
- 一个在前性队列中嵌入的病例控制研究.
- 在诊断前的口腔微生物组样本中进行了枪支元基因组测序.
- 使用条件后勤回归分析微生物多样性,子社区结构和个体种群的分析.
主要成果:
- 在中风病例和对照之间,α和β多样性的显著差异.
- 特定的口腔微生物子社区与降低缺血性中风风险相关 (ORs范围从0.51到0.60).
- 关键的种类,包括 *Corynebacterium*, *Lautropia*, *Lautropia mirabilis* 和 *Neisseria elongate*,都与此有关.
结论:
- 口腔微生物组在缺血性中风的病因学中发挥着作用.
- 需要进一步的研究来探索这种联系.
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