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儿童脑瘤患者的认知和大脑系统分离,这些患者接受了质子疗法治疗

Anna V Dowling¹, Benjamin A Seitzman¹, Timothy J Mitchell¹

¹Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.

International journal of particle therapy

|October 12, 2023

概括

用质子疗法治疗的儿科脑瘤患者表现出大脑网络组织的改变,特别是在关联系统中,与认知缺陷有关. 对海马体的辐射剂量会影响注意力和网络隔离.

科学领域:

神经科学是一个神经科学.
在瘤学瘤学.
医疗成像医学成像

背景情况:

儿科大脑瘤往往导致认知障碍.
休息状态功能性MRI (rsfMRI) 测量大脑网络组织.
质子疗法是儿童大脑瘤的常见治疗方法.

研究的目的:

为了调查质子疗法是否会影响儿童脑瘤患者的大脑网络架构.
为了将大脑网络组织与认知结果和辐射剂量测量相关联.

主要方法:

涉及儿童脑瘤患者认知评估 (NIH工具箱) 和rsfMRI的前性研究.
计算大脑系统分离 (BSS) 来量化大脑网络架构.
分析整个大脑,协会和感官运动系统的网络分离.

主要成果:

患者表现出基线认知缺陷,治疗后恶化.
总体和关联系统BSS在患者与对照人群中明显较低.
右海马辐射剂量与较差的注意力和减少的背部注意力网络分离相关.

结论:

质子疗法与儿科脑瘤患者的大脑网络组织的改变有关,影响认知功能.
协会系统分离受损,而感官运动系统不受影响.
需要进一步研究放射前的rsfMRI,以将瘤/手术效应与辐射效应分开.

关键词:

大脑瘤是个大脑瘤晚期影响后期影响神经认知神经认知质子疗法是一种质子疗法.休息状态的休息状态.

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Brain Imaging

Brain Imaging

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These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).