在乳腺质子疗法期间,心脏导电节点的辐射暴露
Pierre Loap1, Farid Goudjil1, Vincent Servois2
1Department of Radiation Oncology, Institut Curie, Paris, France.
International journal of particle therapy
|October 12, 2023
概括
乳腺辐射疗法,特别是体积调制弧线疗法,可以使鼻腔 (SAN) 和心房 (AVN) 节点暴露在显著的辐射剂量中. 强度调节质子疗法提供了一种潜在的方法来降低这些剂量并减轻心脏风险.
科学领域:
- 辐射瘤学 辐射瘤学
- 心脏病学 心脏病学
- 医学物理 医学物理
背景情况:
- 乳腺辐射治疗期间心脏导电系统 (心房内节[SAN]和心房内节[AVN]) 暴露的研究不足.
- 强度调节辐射疗法 (IMRT) 增加了辐射体积,可能影响心脏结构.
- 卷度调制弧线疗法 (VMAT) 是乳腺癌常见的IMRT技术.
研究的目的:
- 在使用VMAT进行乳房照射期间评估心脏导电节点 (SAN和AVN) 暴露.
- 估计强度调节质子疗法 (IMPT) 对这些关键结构的潜在剂量学益处.
主要方法:
- 在使用VMAT治疗的12名乳腺癌患者的CT扫描上,SAN和AVN的回顾性划分.
- 为这些患者重新规划IMPT.
- 在VMAT和IMPT之间对SAN和AVN的平均和最大辐射剂量进行比较.
- 节点剂量与全心剂量之间的相关性分析.
主要成果:
- VMAT为SAN和AVN提供了相当大的平均和最大剂量,特别是对右侧照射.
- IMPT显著降低了SAN和AVN的平均和最大剂量.
- 在节点剂量和全心剂量之间观察到显著的相关性.
结论:
- 乳房VMAT可以导致显著的SAN和AVN辐射暴露,特别是在右侧治疗中.
- 对传导节点剂量计的进一步研究可能会为心脏节省技术的剂量限制提供信息.
- 在乳腺癌患者中,IMPT和呼吸道门显示有望降低心脏剂量和潜在心脏毒性.
相关概念视频
Biological Effects of Radiation
15.5K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.5K
Radiological Investigation III: Pulmonary Angiogram and PET Scan
98
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
98
Radiation: Applications
1.2K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
The average...
1.2K
Cardiac Catheterization IV: Nursing Management
31
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
31
Imaging Studies for Cardiovascular System III: X-Ray
194
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
194
Imaging Studies for Cardiovascular System V: CT
22
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
22


