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2期质子疗法临床试验中的种族和民族人口报告:一篇综述

Jonathan S Fakhry¹, M Juliana Pena¹, Ariel Pomputius²

¹Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL, USA.

International journal of particle therapy

|October 12, 2023

概括

已发表的2期质子疗法试验显示,种族和民族人口统计数据的报道显著不足. 黑人和西班牙裔患者的代表性严重不足,这凸显了解决参与障碍的必要性.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
临床试验研究临床试验研究

背景情况:

公平地将患者纳入临床试验对于解决医疗保健差异至关重要.
历史上被边缘化的人群面临着参与医学研究的重大障碍.

研究的目的:

描述美国公布的质子疗法第二阶段临床试验中患者的种族和种族人口统计.
确定在质子疗法研究中不同患者群体代表性的潜在差异.

主要方法:

使用主要科学数据库 (PubMed,Embase,World of Science,Cochrane) 发表的2期质子疗法临床试验的系统审查.
数据提取包括患者的种族/种族,瘤部位和试验特征,遵守PRISMA指南.
分析的重点是包括的试验中的种族和民族群体的报告和代表性.

主要成果:

在38项符合条件的试验 (2648名患者) 中,只有39%的人报告了种族/种族数据.
在报告数据的患者中 (n=1409),89%是非西班牙裔白人,5.3%是黑人,2.2%是西班牙裔.
与一般人口人口统计数据相比,观察到黑人和西班牙裔患者的代表性明显不足.

结论:

已公布的2期质子疗法试验显示,患者人口统计数据的报告不足.
在这些试验中,黑人和西班牙裔患者的代表性明显不足,反映了癌症药物试验中出现的问题.
迫切需要识别和克服黑人和西班牙裔患者参与质子疗法试验的障碍,以确保在放射性瘤学研究中得到公平的代表.

关键词:

人口统计数据人口统计数据第二阶段的试验.质子疗法是一种质子疗法.竞争竞争竞争竞争

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