高压氧疗法作为神经母细胞瘤的补充治疗 - - 一个叙事审查
Diogo Alpuim Costa1,2,3,4,5, J Guilherme Gonçalves-Nobre5,6,7,8,9, Mafalda Sampaio-Alves9,10
1Hematology and Oncology Department, CUF Oncologia, Lisbon, Portugal.
Frontiers in oncology
|October 12, 2023
概括
神经母细胞瘤是一种常见的儿童癌症,由神经细胞产生的. 本综述探讨了其病理生理学,临床方面和管理,包括治疗耐药性的高压氧疗法 (HBOT).
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症生物学 癌症生物学
- 医学物理 医学物理
背景情况:
- 神经母细胞瘤是婴儿中最常见的癌症,起源于神经细胞.
- 它的临床表现和预后因年龄,阶段和生物因素的影响而有很大差异.
- 瘤缺氧是神经母细胞瘤对传统疗法的抵抗的一个关键因素.
研究的目的:
- 审查神经母细胞瘤的病理生理学,临床表现和生物/遗传特征.
- 讨论当前的神经母细胞瘤管理策略.
- 探索高压氧气疗法 (HBOT) 在治疗神经母细胞瘤中的潜在作用.
主要方法:
- 关于神经母细胞瘤病理生理学,临床表现和管理的文献综述.
- 专注于研究研究高压氧气疗法 (HBOT) 作为一种补充治疗.
- 对影响神经母细胞瘤行为的生物和遗传因素的分析.
主要成果:
- 神经母细胞瘤表现出不同的临床行为和预后.
- 多模式治疗,包括化疗,放射治疗,免疫治疗和手术,是标准的.
- HBOT正在研究其减轻瘤缺氧和提高治疗疗效的潜力.
结论:
- 了解神经母细胞瘤的复杂生物学对于风险分层和治疗至关重要.
- 在神经母细胞瘤中,HBOT是一种有前途的辅助疗法,可以克服治疗耐药性.
- 需要进一步的研究来充分阐明HBOT在神经母细胞瘤管理中的作用.
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