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由Dioscorea opposita Thunb.所施加的抗肥胖作用. 饮食引起的肥胖小鼠中的多糖

Sheng-Nan Li¹, Dian-Long Zhang¹, Zhen-Hui Wang¹

¹School of Medicine Henan Polytechnic University Jiaozuo China.

Food science & nutrition

|October 12, 2023

概括

来自迪奥斯科雷亚对立的多糖体 Thunb. (DOTPs) 通过减少小鼠的体重,炎症和胰岛素抵抗来对抗肥胖. DOTP还可以改善肠道微生物群平衡,提供一种潜在的天然抗肥胖干预措施.

科学领域:

营养科学营养科学
微生物学微生物学
代谢障碍代谢障碍代谢障碍

背景情况:

肥胖与慢性炎症,胰岛素抵抗和肠道疾病有关.
迪奥斯科雷亚对立的. (DOTPs) 是一个传统的中国食品和医药.
肠道微生物群的变化与肥胖病原性有关.

研究的目的:

为了研究DOTPs的抗肥胖作用.
为了确定DOTPs对肠道微生物群组成和代谢在饮食诱导的肥胖的影响.
评估DOTPs对炎症和胰岛素抵抗的影响.

主要方法:

从 Dioscorea opposita Thunb. 的水提取物中分离出DOTP.
用高脂肪饮食 (HFD) 养的小鼠作为肥胖模型.
分析了体重,脂肪积累,胰岛素抵抗,炎症标志物和肠道微生物群.

主要成果:

在HFD小鼠中,DOTPs降低了体重,脂肪组织积累和胰岛素抵抗.
DOTPs调节了肠道微生物群,降低了Firmicutes与Bacteroidetes的比率.
DOTPs增加了Akkermansia水平并降低了Ruminiclostridium_9,同时降低了糖解代谢.

结论:

在饮食诱导的肥胖小鼠中,DOTPs表现出显著的抗肥胖作用.
DOTPs通过抑制全身炎症和改善肠道微生物群失生症来改善肥胖症.
DOTPs是治疗肥胖和相关代谢障碍的一种有前途的天然化合物.

关键词:

迪奥斯科雷亚对立的.我们的肠道微生物群.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖聚糖类是一种多糖类.

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