神经性厌食症的新治疗方法:来自神经可塑性研究的见解
Johanna Louise Keeler1,2, Carol Kan3, Janet Treasure1,2
1King's College London, Centre for Research in Eating and Weight Disorders (CREW), Institute of Psychiatry, Psychology & Neuroscience, Department of Psychological Medicine, London, UK.
概括
由于神经可塑性缺陷,神经性厌食症 (AN) 的治疗很困难. 针对这些神经生物学变化的新疗法,包括药物和专门的心理疗法,有望改善AN患者的治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 神经性厌食症 (AN) 治疗具有挑战性,有效干预措施有限.
- 人们越来越认识到AN的神经生物学基础,特别是神经可塑性缺陷.
- 了解急性阶段的AN神经生物学对于开发基于证据的治疗方法至关重要.
研究的目的:
- 审查与AN神经可塑性相关的神经生物学发现.
- 将这些发现转化为新的治疗策略.
- 探索心理药物学和心理治疗方法.
主要方法:
- 神经成像,神经心理学,分子和定性研究的综合性审查.
- 在神经性厌食症的背景下分析神经可塑性的研究.
- 综合发现,为治疗发展提供信息.
主要成果:
- 潜在的精神药理疗法包括胺,西和瘦素,针对神经可塑性.
- 抗炎药物和来自大脑的神经营养因子 (BDNF) 模仿剂是潜在的未来途径.
- 心理治疗策略,如图像重写,认知补救和基于正念的干预措施,可以解决神经可塑性缺陷.
结论:
- 需要专门针对AN的神经生物学后果的治疗方法.
- 用纵向设计和更大的样本进行进一步的研究是必不可少的.
- 需要进行可行性研究,以支持AN治疗的翻译努力.
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