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在涉及外部对照数据的早期随机临床试验中估计治疗效应

Heiko Götte1, Marietta Kirchner2, Johannes Krisam2

  • 1Global Biostatistics, Merck Healthcare KGaA, Darmstadt, Germany.

Journal of biopharmaceutical statistics
|October 12, 2023
PubMed
概括

将外部对照数据与随机对照试验 (RCT) 结合起来,可以减少治疗效果估计的变化. 结合结果和基线共变量数据的分析方法在可靠结果方面表现最好.

关键词:
药物开发的早期阶段在RMSE中,它是RMSE.估计估计估计的估计.外部控制数据的数据.时间到事件数据.

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