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非常早产婴儿的凝血参数
Beril Yasa1, Elif Kirit, Asuman Coban
1Istanbul University, Istanbul Medical Faculty, Department of Pediatrics, Division of Neonatology, Istanbul, Turkey.
概括
这项研究确定了32周妊娠年龄以下的早产婴儿的正常凝血参数范围. 确定这些百分比的前血时间和激活的局部血质蛋白时间有助于解释结果并减少不必要的治疗.
科学领域:
- 新生儿医学 新生儿医学
- 儿科血液学 儿科血液学
- 临床凝血 临床凝血
背景情况:
- 在早产婴儿 (<32周妊娠年龄) 的凝血参数还不清楚.
- 在非常早产的新生儿中,不成熟的凝血系统会增加出血风险.
- 准确解释凝血试验对于适当的临床管理至关重要.
研究的目的:
- 在早产婴儿中确定前血时间 (PT) 和激活的部分血栓形成时间 (aPTT) 的正常百分位值.
- 定义基于妊娠年龄和出生体重类别的参考范围.
- 提供数据,以便更好地解释这种脆弱人群中的凝血状况.
主要方法:
- 在2011-2021年间出生的420名早产儿进行了回顾性队列研究.
- 在干预之前通过管导管获得的血液样本分析的凝血参数 (PT,aPTT).
- 婴儿按妊娠年龄 (<24,25-26,27-28,29-30,31-32周) 和出生体重 (<500克至>1500克) 分组.
主要成果:
- 孕期年龄子组中的前血时间 (PT) 值相似,但在婴儿<1000g出生体重时延长.
- 在怀孕24周以下的婴儿中,激活的部分血栓形成时间 (aPTT) 值显著更长.
- 对PT和aPTT的正常百分位数范围 (第3至第97) 定义了各种妊娠年龄和出生体重层.
结论:
- 非常早产的婴儿 (<32周妊娠年龄) 具有不成熟的凝血系统,增加出血风险.
- 已确定的PT和aPTT百分值将有助于准确解释早产新生儿的凝血测试.
- 这些数据可能有助于尽量减少不适当的新鲜冷血 (FFP) 在早产婴儿的管理.
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