一个大学医院的与毒品有关的死亡:与过去几十年的比较
Mirjam Kauppila1,2,3, Janne T Backman1,2,3, Mikko Niemi1,2,3
1Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland.
Basic & clinical pharmacology & toxicology
|October 12, 2023
概括
致命的药物不良反应 (ADRs) 仍然是一个问题,2019年5.3%的医院死亡与ADRs有关. 药物趋势呈现出转变,直接口服抗凝剂导致的致命出血比华法林更多.
科学领域:
- 药物监督 药物监督 药物监督
- 医院安全 医院安全
- 药物安全研究 药物安全研究
背景情况:
- 药物不良反应 (ADR) 是医院死亡的一个重要原因,但其发生率和趋势尚不清楚.
- 评估医疗安全过程对ADR的影响是具有挑战性的,因为医疗实践报告不足和不断变化.
研究的目的:
- 确定目前在大学医院致命的副作用的发生率和特征.
- 为了将当代致命的ADR数据与同一机构的两项先前研究的发现进行比较.
- 为了确定致命的副作用和相关药物类别的趋势.
主要方法:
- 追溯分析2019年赫尔辛基大学医院发生的1236起死亡事件.
- 专家团队对所有死亡病例的评估,以使用WHO和乌普萨拉监测中心的类别来评估因果关系.
- 从分析中排除了自杀病例.
主要成果:
- 在死亡人数中发现了65例确定的或可能的ADR病例 (5.3%),占住院人数的0.011%.
- 细胞静止剂和抗血栓剂是最常见的药物类别,涉及致命的副作用.
- 直接口服抗凝剂的致命出血增加,而与华法林相关的出血减少;对比剂和胰岛素没有导致致命的副作用.
结论:
- 致命的不良反应仍然是大学医院的一个关键问题,特定的药物类别带来更高的风险.
- 药物使用的变化,例如直接口服抗凝剂的增加,反映在ADR趋势中.
- 提高药监意识可能有助于减少某些药物的致命副作用,例如对比剂和胰岛素.
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