对阿片类药物的不良药物反应:国家药监数据库中的一项研究
Moa Gustafsson1,2, Cristiano Matos3, João Joaquim3
1Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. moa.gustafsson98@icloud.com.
Drug safety
|October 12, 2023
概括
像恶心和吐这样的阿片类药物不良反应 (ADRs) 是常见的,女性报告吐更多与tramadol. 在荷兰的自发报告系统中,阿片类药物对滥用,滥用和药物错误的报告不成比例.
科学领域:
- 药监和药物安全 药监和药物安全
- 临床药理学 临床药理学
- 疼痛管理 疼痛管理
背景情况:
- 阿片类药物是必不可少的止痛药,但具有不良药物反应 (ADR) 的风险,包括呼吸系统抑郁等严重事件.
- 在临床实践中监测阿片类药物安全性至关重要,因为潜在的有害和致命的结果.
研究的目的:
- 用自发报告系统 (SRS) 来描述荷兰阿片类药物的安全概况.
- 调查与阿片类药物相关的滥用,滥用,药物错误以及ADR报告中的基于性别的差异.
主要方法:
- 一项描述性研究分析了来自荷兰药监中心Lareb (2003-2021) 的8769份报告.
- 报告几率比率 (RORs) 计算了药物-ADR组合,并对性别和药物使用进行了校正.
主要成果:
- 恶心,头和吐是最常见的阿片类药物不良反应,在女性中报告的更多.
- 在女性中,特拉马多尔的吐报告显著增加 (ROR 2.17).
- 芬太尼与大多数滥用,滥用和药物错误的报告有关;当为支出进行校正时,布普伦诺非因与应用部位反应相关的副作用很高.
结论:
- 吸食阿片类药物与显著的副作用有关,观察到一些性别特异性差异,特别是特拉马多尔诱导的吐.
- 与荷兰SRS中的其他药物相比,阿片类药物滥用,滥用和药物错误报告率不成比例地高.
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