激活NIR的向Janus纳米引擎重塑免疫抑制瘤微环境用于增强癌症免疫疗法
Xiaoyu Zhou1,2, Enhui Ma3, Yingying Zhang1
1School of Medical Imaging, Xuzhou Medical University, 221006, Xuzhou, China.
Advanced healthcare materials
|October 12, 2023
概括
斯纳米引擎将易布鲁替尼传递给与瘤相关的巨细胞,重编程它们以增强癌症免疫疗法. 这种有针对性的方法可以改善药物输送和抗瘤免疫反应.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症研究 癌症研究
背景情况:
- 具有M2表型的瘤相关巨细胞 (TAM) 促进瘤生长和转移.
- 易布鲁替尼 (IBR) 可以将TAM复极化为M1表型,但其可溶性差限制了疗效.
- 将IBR有效地传递给TAMs对于改善癌症免疫疗法至关重要.
研究的目的:
- 开发Janus纳米发动机,以便在固体瘤中有效地将IBR传递给TAM.
- 为了研究纳米发动机的NIR激光驱动推进和准能力.
- 评估纳米电机在反极化TAM和激活抗瘤免疫力的有效性.
主要方法:
- 简斯纳米发动机被合成并装载IBR和盐酸 (MSA) 进行准.
- 接近红外线 (NIR) 激光照射被用来通过自我热泳来启动纳米电机推进.
- 在体外和体内研究评估了纳米运动吸收,TAM复极化和抗瘤免疫反应.
主要成果:
- 在NIR照射下,Janus纳米发动机在NIR照射下实现了12.15μm s-1的推进速度.
- 纳米运动介导的IBR输送在体外显著增强了M2到M1TAM再极化.
- 在体内研究表明,瘤积累,透和T细胞激活得到改善.
结论:
- 由NIR激光激活的Janus纳米引擎提供了一个有前途的战略,用于针对性地将IBR传递给TAM.
- 这种方法有效地重塑了免疫抑制瘤微环境,并增强了癌症免疫疗法.
- 合成的IC@MSA JNMs显示了改善固体瘤中药物输送和治疗结果的潜力.
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