在状腺腺瘤的多形腺瘤中发生癌症的风险
Helena Levyn1, Tejas Subramanian2, Alana Eagan1
1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
JAMA otolaryngology-- head & neck surgery
|October 12, 2023
概括
形腺瘤 (PAs) 恶性转化为前形腺瘤 (CXPA) 癌症发生在3.2%的未经治疗的病例中. 较大的瘤大小和较大的年龄,而不是瘤持续时间,与CXPA发育有关.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术病理学手术病理学
- 在瘤学瘤学.
背景情况:
- 外科手术是状形腺瘤 (PAs) 的首要治疗方法,以防止恶性转变.
- 目前关于未经治疗的PAS恶性转变率的数据有限.
研究的目的:
- 为了确定未经治疗的PAS中癌细胞前形腺瘤 (CXPA) 的发生率.
- 确定与PA中恶性瘤发展相关的因素.
主要方法:
- 一项队列研究审查了260名在1990年至2015年期间管理的初级PA患者.
- 分析了瘤持续时间,大小和患者年龄与CXPA检测的关联.
- 病理学幻灯片由专家病理学家审查CXPA诊断.
主要成果:
- 在3.2%的未经治疗的PA中检测到CXPA.
- 瘤大小 (OR,1.66) 和年龄增加 (OR,1.04) 与CXPA相关.
- 瘤持续时间与CXPA发育没有显著关联 (OR,1.00).
结论:
- 在未经治疗的PA中,恶性转化率为3.2%.
- 瘤大小和患者年龄是CXPA的风险因素,而持续时间不是.
- 在没有立即干预的情况下观察PAs并没有导致永久性并发症.
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