在COVID-19患者中,肝损伤和肝壮病
Pınar Yürük Atasoy1, Engin Beydoğan2
1Department of Infectious Diseases, Ankara City Hospital, Ankara, Turkey.
Journal of infection in developing countries
|October 12, 2023
概括
在没有先前存在肝病的COVID-19患者中,高肝功能测试没有影响结果. 然而,肝膨胀和升高的LDH和CK水平与COVID-19患者的严重疾病和死亡率有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- 在一些2019年冠状病毒病 (COVID-19) 患者中观察到肝功能测试 (LFT) 的升高.
- 在没有先前存在肝病的COVID-19患者中,异常LFT和肝脏大小的临床意义尚不清楚.
研究的目的:
- 评估住院COVID-19患者肝功能测试升高和临床结果之间的关联.
- 确定COVID-19患者中严重疾病和死亡率的预测因素.
主要方法:
- 对367名住院COVID-19患者的回顾性分析.
- 收集的数据包括肝功能测试,C-反应蛋白,腹部超声波检测结果和临床结果.
- 进行了统计分析,以确定与疾病严重程度和死亡率相关的因素.
主要成果:
- 在患有严重COVID-19和死亡率 (p < 0.001) 的患者中,肝扩大明显更频繁 (p < 0.001).
- 乳酸脱酶 (LDH) 和肌酸激酶 (CK) 水平升高被确定为死亡风险因素 (分别p < 0.001和p = 0.032).
- 在没有急性/慢性肝病的患者中,LFTs的升高与临床结果无关.
结论:
- 在没有先前存在的肝病的住院COVID-19患者中,LFT升高和肝脏大小增加似乎不会影响临床结果.
- 晚年,并发病,肝壮病,以及升高的LDH和CK水平与COVID-19的不良临床结果有关.
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