增加COVID-19感染后多病症风险:疫苗接种的保护作用
1Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, Centre for Safe Medication Practice and Research, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, China.
QJM : monthly journal of the Association of Physicians
|October 12, 2023
概括
冠状病毒疾病2019 (Covid-19) 感染显著增加了患有一种慢性疾病的个体的多病症风险. 完全接种疫苗可以大大减轻这种高风险,提供至关重要的保护.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- COVID-19大流行对先前存在慢性疾病的个体多病发病率的影响尚不清楚.
- 疫苗接种对这种关联的潜在修饰作用需要研究.
研究的目的:
- 调查Covid-19感染与多病发病率之间的关联.
- 评估先前接种疫苗在改变患有一种慢性疾病的个体中这种关联中的作用.
主要方法:
- 一项全境嵌套病例控制研究,利用香港的电子健康记录和Covid-19报告.
- 发病率密度采样匹配了病例 (发展多病症) 和对照 (没有发展多病症).
- 条件后勤回归分析以确定多病症的调整几率比率 (aORs).
主要成果:
- 在COVID-19感染后,多发病率增加了28% (CI22%-36%).
- 之前完全接种疫苗 (BNT162b2或CoronaVac) 显示,多发病率 (CI -2%-7%) 增加了3%,但不显著.
- 这些关联在不同的人口群体 (包括年龄和性别) 中是一致的.
结论:
- 感染Covid-19显著提高了患有一种先前存在的慢性疾病的个体发展多病症的风险.
- 完全接种疫苗显示出显著的保护作用,降低了COVID-19后多发病症风险的增加.
更多相关视频
06:03Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
Published on: September 20, 2024
1.3K
09:37Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
1.9K
相关概念视频
Vaccinations
44.6K
Overview
44.6K
Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
Immunological Memory
637
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
637
Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K
Cross-reactivity
31.2K
Overview
31.2K
Cancer Vaccines
384
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
384
