2型糖尿病与老年患有情绪障碍的躁狂发病率有关
Francesco Weiss1, Giulio Emilio Brancati1, Camilla Elefante1
1Department of Clinical and Experimental Medicine, University of Pisa, Pisa.
International clinical psychopharmacology
|October 12, 2023
概括
2型糖尿病 (T2DM) 与老年患者情绪障碍的恶化有关. 这包括增加的血管和神经认知问题,以及双相情感障碍 (BD) 患者的躁狂发作.
科学领域:
- 老年精神病学是一门精神病学专业.
- 代谢障碍 代谢障碍 代谢障碍
- 神经科学是一个神经科学.
背景情况:
- 情绪障碍,特别是双相情绪障碍 (BD) 与代谢障碍之间的联系已经确立.
- 代谢障碍对晚年情绪障碍进展的影响仍未得到充分研究.
研究的目的:
- 研究2型糖尿病 (T2DM) 对老年人 (≥65岁) 情绪障碍的进展的影响.
主要方法:
- 对患有重度抑郁症或BD的老年患者的回顾性图表审查.
- 患者被跟踪至少18个月,并根据T2DM并发性疾病进行分类.
- 统计分析比较了患有T2DM和没有T2DM的患者之间的结果.
主要成果:
- 患有T2DM的患者表现出较高的血管脑病变和神经认知障碍.
- T2DM与躁狂发作的随访时间比例更高和躁狂发作的发病率更高有关.
- 当分析仅限于患有双极性谱系障碍的患者时,这些发现是一致的.
结论:
- 2型糖尿病与情绪障碍,特别是双相情绪障碍的老年患者的不良疾病过程有关.
- 在患有BD的老年人中,T2DM可能会加剧认知和血管并发症,并增加躁狂发作频率.
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