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冷诱导的lncRNA266促进了白色脂肪组织中的棕色化和发热程序

Jinyu Ma¹, Yuting Wu¹, Lixue Cen¹

¹Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, NMPA Key Laboratory of Research and Evaluation of Tissue Engineering Technology Products, School of Medicine, Nantong University, Nantong, China.

|October 12, 2023

概括

暴露在寒冷中会诱导白色脂肪中的长非编码RNA lnc266. 这种RNA促进棕色脂肪的发展,促进新陈代谢,有助于减肥,改善肥胖小鼠的寒冷耐受性.

科学领域:

代谢调节代谢调节代谢调节
脂肪组织生物学脂肪组织生物学
基因表达调节基因表达调节

背景情况:

不的热生成对于代谢健康和对抗肥胖至关重要.
长非编码RNAs (lncRNAs) 越来越多地被认为是它们在棕色脂肪组织 (BAT) 功能中的作用.
了解热生成的新型调节者是开发肥胖治疗的关键.

研究的目的:

为了研究 lncRNA lnc266 在冷诱导热生成中的作用.
阐明Inc266影响白脂肪色和能源消耗的机制.
评估lnc266在肥胖和代谢功能障碍中的治疗潜力.

主要方法:

在寒冷暴露后,脂肪组织中 lncRNA 表达的分析.
在体外研究脂肪细胞分化和基因表达.
在寒冷条件下对肥胖小鼠进行体内研究.
涉及微RNA海绵化 (miR-16-1-3p) 和Ucp1调节的机制研究.

主要成果:

lnc266在部白脂肪组织 (iWAT) 中的寒冷显著诱导.
lnc266在体外促进棕色脂肪细胞的分化和发热基因表达.
在肥胖小鼠中,Inc266增强了白色脂肪的色,增加了核心体温,并减少了寒冷中的体重增加.
lnc266通过海绵化miR-16-1-3p来发挥作用,从而缓解miR-16-1-3p介导的Ucp1.1抑制.

结论:

lnc266是iWAT中的一个关键的冷诱导 lncRNA,驱动热生成程序.
lnc266促进白色脂肪的色,并改善全身能量代谢.
lnc266代表了肥胖和相关代谢障碍的潜在治疗标.

关键词:

在UCP1中,UCP1是UCP1.在 lncRNAs 中.在 miR16-1-3p 中使用.热源性基因是热源性的基因.白色脂肪棕色化棕色化

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...