在接受新辅助化疗和放射治疗的局部晚期直肠癌患者中,使用术后MRI纤维化得分来研究直肠功能:一项两中心研究
Yuan Yuan1, Yue Yu2, Yi Qun Sun3
1Department of Radiology, Shanghai Changhai Hospital, Shanghai, China.
Annals of medicine
|October 12, 2023
概括
手术后的MRI纤维化得分与直肠功能相关,直肠癌患者接受了新辅助化学放射治疗 (nCRT). 一个新的评分系统有效地预测治疗后的功能结果.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 手术研究的研究.
背景情况:
- 局部晚期直肠癌 (LARC) 治疗通常涉及新辅助化学放射治疗 (nCRT).
- 评估术后的结果,特别是直肠功能,对于患者的生活质量至关重要.
- 需要使用标准化方法来预测nCRT后的功能性结果.
研究的目的:
- 在LARC中开发一种基于MRI的新型评分系统,用于在nCRT后评估纤维化.
- 评估这种纤维化评分系统与术后直肠功能之间的相关性.
- 使用MRI衍生纤维化指标建立门功能预测模型.
主要方法:
- 对接受nCRT和激光切除的病理确诊LARC患者的回顾性分析.
- 基于手术后的MRI,解剖纤维化得分 (AFS) 和直周纤维化得分 (PFS) 的发展.
- 与手术后2年获得的韦克斯纳失禁分数的相关性分析.
- 使用单变量和多变量分析,ROC和DCA构建和验证一个名ogram模型.
主要成果:
- 分析了培训组中的144名患者和验证组中的52名患者.
- AFS和PFS与韦克斯纳分数呈正相关性.
- 年龄,瘤高度,AFS和PFS被确定为直肠功能的独立预测因素.
- 诺莫格拉姆模型显示出良好的诊断性能 (AUC为0.800和0.827).
结论:
- 术后MRI衍生的AFS和PFS与韦克斯纳分数正相关.
- 开发的纤维化评分系统有效地预测了LARC患者在nCRT后的直肠功能.
- 这种评分系统为评估长期功能结果提供了有价值的工具.
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