在新皮质的轴突初始段和远端轴突中触发的作用潜力的时间差异
Márton Rózsa1, Martin Tóth1, Gáspár Oláh1
1ELKH-SZTE Research Group for Cortical Microcircuits, University of Szeged, Szeged, Hungary.
Science advances
|October 12, 2023
概括
皮层内部神经元表现出两种类型的动作潜力:在轴突初始段 (AIS-APs) 启动的动作潜力和在远端轴突 (RA-APs) 自发发生的动作潜力. 这些独特的发射模式影响着个体神经元如何为网络活动做出贡献.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 细胞神经科学 细胞神经科学
背景情况:
- 神经群活动决定了皮层神经元的突触输入时间.
- 轴突初始段 (AIS-APs) 中的动作潜能启动与网络振荡相锁.
- 逆轴子动力潜能 (RA-APs) 可以在远端轴突中实验诱导,但它们的自发发生是未知的.
研究的目的:
- 调查皮层内神经元中逆轴突作用电位 (RA-AP) 的自发发生和特性.
- 为了比较来自同一内部网络的AIS-AP和RA-AP的网络贡献.
主要方法:
- 在人体和动物皮层内部神经元中的体内电生理记录.
- 分析自发动作潜能活动的分析.
- 在AIS-AP和RA-AP之间的时间比较.
主要成果:
- 在皮层内部神经元中观察到自发发生的RA-AP.
- 这些RA-AP与突触输入和整体网络活动无关.
- 在同一个内部神经元中,AIS-AP和RA-AP表现出不同的时间点火模式.
结论:
- 皮层内部神经元除了输入驱动的AIS-AP外,还可以生成输入独立的RA-AP.
- 由于AIS-AP和RA-AP的时间不同,导致单个内部神经元对网络功能的时间贡献不同.
- 这种双重触发机制为单个神经元提供了一种新的方式来调节网络动态.
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