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针对固体瘤的益生菌引导的CAR-T细胞

Rosa L Vincent¹, Candice R Gurbatri¹, Fangda Li²

¹Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.

Science (New York, N.Y.)

|October 12, 2023

概括

工程细菌为瘤提供合成点,引导仿真抗原受体 (CAR) - T细胞杀死抗原无关的癌细胞. 在临床前的癌症模型中,这种益生菌导向的CAR-T细胞疗法 (ProCAR) 是有前途的.

科学领域:

癌症学
微生物学
免疫疗法

背景情况:

针对固体瘤的治疗因瘤异质性和缺乏特定抗原而面临挑战.
细菌可以选择性地殖民瘤,并作为工程治疗交付平台.

研究的目的:

开发一种结合益生菌和CAR-T细胞用于向癌症治疗的新平台.
在固体瘤中克服抗原特异向的局限性.

主要方法:

为了释放合成瘤目标,
开发了益生菌引导的CAR-T细胞 (ProCARs) 用于在位瘤标记和溶解.
在人类和小鼠癌症的异种移植和同源模型中测试了ProCARs.
合成的益生菌可同时释放化学基因, 增强CAR-T细胞的招募能力.

主要成果:

ProCARs证明了CAR- T细胞的激活和抗原无关的瘤细胞溶解.
该系统在多种临床前癌症模型中安全有效.
多功能益生菌增强了CAR- T细胞的招募和治疗反应.

结论:

益生菌引导的CAR-T细胞提供了针对固体瘤的可行策略.
这种方法可以杀死抗原独立的癌细胞,并增强免疫疗法.
进一步开发工程益生菌可以改善基于CAR-T细胞的癌症疗法.

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