通过它们的时间表达模式对精神分裂症基因进行分组,有助于功能解释
Dennis van der Meer1,2, Weiqiu Cheng1, Jaroslav Rokicki1,3
1Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Schizophrenia bulletin
|October 12, 2023
概括
精神分裂症的发展涉及不同的产前和产后基因表达模式. 在产前发育期间的遗传风险与产后风险相互作用,影响精神分裂症的诊断.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 发展生物学 发展生物学
背景情况:
- 精神分裂症是一种高度遗传的脑部疾病,在成年早期发作.
- "二击"假设表明早期的神经发育倾向,随后是晚期成熟中断触发症状.
研究的目的:
- 研究不同基因表达模式在精神分裂症神经发育中的作用.
- 探索精神分裂症病因学的不同发育阶段的多基因风险评分的相互作用.
主要方法:
- 在整个生命周期中,从皮质组织中分组了345个精神分裂症相关基因.
- 在精神分裂症患者和对照人群中计算集群特异性多基因风险得分.
- 在独立的临床队列中进行复制.
主要成果:
- 确定了两个基因组:一个在产前 (细胞周期) 上调的,一个在产后 (免疫/神经元通信) 上调的.
- 发现了显著的相互作用:较高的产前多基因风险在较高的产后多基因风险水平上放大了与精神分裂症的关联.
- 在3233个个体的独立队列中重复发现.
结论:
- 精神分裂症在特定的神经发育阶段的不同生物过程中受到干扰的影响.
- 基因与环境相互作用的建模,通过发育时间来告知,增强了对精神分裂症发展的理解.
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