抗生素耐药性特征和Enterococcus的分子特征 在中国从组合益生菌制剂中分离的物种
Xin Jin1, Rui Cai2, Ruirong Wang1
1Nanjing Institute for Food and Drug Control, Jiangsu, Nanjing, China.
Foodborne pathogens and disease
|October 12, 2023
概括
在益生菌中发现的抗生素耐药性肠球菌带来风险. 这些细菌携带着众多的耐药性和毒性基因,强调需要仔细选择益生菌来防止抗菌素耐药性的传播.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 肠球菌是已知的抗生素耐药基因的储存库.
- 这些基因可以转移到其他胃肠道细菌.
- 益生菌制剂可能含有潜在有害的肠球菌株.
研究的目的:
- 描述从益生菌中分离出来的肠球菌的抗生素耐药性.
- 为了确定耐药性和毒性因子的分子基础.
- 评估益生菌产品中肠球菌的安全影响.
主要方法:
- 使用16S rDNA测序从益生菌样本中分离和识别肠球菌.
- 通过微稀释方法进行抗微生物敏感性测试.
- 全基因组测序用于耐药性基因和毒性因子分析.
主要成果:
- 广泛的耐药性观察到硫甲醇,诺弗洛克萨,阿齐思罗米,和 gentamicin.
- 所有分析的菌株都具有多个抗生素耐药性基因和多种药物排泄基因.
- 在E. faecalis*中发现了新的氨基醇耐药基因 (ykkC, ykkD).
- 在所有菌株中检测到大量的毒性因子和基因岛屿.
结论:
- 益生菌制剂可以含有抗生素耐药性肠球菌,具有令人担忧的遗传特征.
- 耐药性和毒性基因的存在表明与益生菌使用相关的潜在风险.
- 仔细选择益生菌产品至关重要,以减轻抗菌素耐药性和致病性的传播.
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