西尼罗河病毒的新预后参数:血小板分布宽度
Ahmed Cihad Genc1, Oğuz Karabay2, Ertuğrul Güçlü2
1Department of Internal Medicine, Hendek State Hospital, Sakarya, Turkey.
Vector borne and zoonotic diseases (Larchmont, N.Y.)
|October 12, 2023
概括
西尼罗病毒 (WNV) 感染是发烧性疾病的原因,可以通过血小板分布宽度 (PDW) 的升高来识别. 超过17.85%的PDW显著增加了WNV感染风险,并有助于差异诊断.
科学领域:
- 医学昆虫学 医学昆虫学
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 西尼罗河病毒 (WNV) 引起发烧性疾病和脑膜炎,特别是在夏季晚些时候.
- 蚊子传播的 arbovirus 是一个重要的公共卫生问题.
研究的目的:
- 为了确定WNV脑炎的危险因素.
- 为了评估WNV感染的诊断标志物.
主要方法:
- 一项病例控制研究比较了已确认WNV感染的患者与具有类似症状但测试结果为负的患者.
- 诊断标准包括阳性WNVPCR和抗体测试.
- 统计分析发现实验室标记物的显著差异.
主要成果:
- 确定了26个WNV病例和22个对照病例.
- 在C-反应蛋白,前素,ESR,性酸酶,血小板计数和PDW中观察到显著差异.
- 一个PDW>17.85%显示了82%的敏感性和91%的特异性WNV感染,增加了6.1倍的风险.
结论:
- 发烧和混乱是WNV感染的关键指标.
- 在9月和10月出现发烧和混乱的患者的差异诊断中应考虑WNV,特别是在沿着鸟类迁徙路线的地区.
- 血小板分布宽度 (PDW) 的百分比可以帮助对WNV病例的差异诊断.
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