相关实验视频

Updated: Jun 24, 2026

Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

Published on: June 16, 2020

磁性Fe₃O₄/CeO₂"核心/外"类纳米复合材料的设计,具有明显的抗胺基因和抗氧化生物活性

Yuliia Shlapa¹, Katarina Siposova², Katerina Veltruska³

¹V. I. Vernadsky Institute of General and Inorganic Chemistry of the National Academy of Sciences of Ukraine, 32/34 Palladina Avenue, Kyiv 03142, Ukraine.

ACS applied materials & interfaces

|October 12, 2023

概括

磁性Fe3O4 / CeO2纳米复合材料提供增强的抗氧化和抗胺原性质. 它们的核心/外结构允许在交替磁场 (AMF) 中进行可调节的加热,从而改善生物医学应用.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

结合磁性Fe3O4和氧化还原活性CeO2纳米颗粒 (NP) 的核心/外纳米复合材料对生物医学应用具有前景.
这些材料利用Fe3O4NP在交替磁场 (AMF) 中的高热潜力和CeO2NP的抗氧化特性.

研究的目的:

为了合成和描述Fe3O4/CeO2核心/外纳米复合材料 (NCPs).
评估这些NCP的稳定性,磁加热效率和生物医学活动 (抗氧化剂,抗胺基因).

主要方法:

通过CeO2外沉到预先成型的Fe3O4NP上合成Fe3O4/CeO2NP.
使用X射线衍射 (XRD),X射线光电子光谱 (XPS) 和高分辨率传输电子显微镜 (HRTEM) 的表征.
评估水悬浮中的稳定性 (ζ-潜力),AMF中的磁性加热,抗氧化活性 (超氧化解酶类) 和抗胺基活性 (胰岛素胺基形成抑制).

主要成果:

形成Fe3O4/CeO2核心/外NCPs与围绕Fe3O4核心的超细CeO2NPs (3-3.5nm).
对于具有5和7纳米CeO2外的NCP,在水悬浮中提高稳定性 (>+30 mV ζ-潜力).
国家核电站保留了高效的AMF加热能力,可调节的最高温度 (42-50°C) 由外厚度控制.
抗氧化和抗胺基因活性显著改善;7纳米外NCP显示,胰岛素胺基因抑制的IC50降低了约10倍,SOD类活性比纯CeO2高了2倍.

结论:

Fe3O4/CeO2核心/外NCP表现出增强的稳定性和可调节的高温.
Fe3O4和CeO2的协同作用组合显著增强了抗氧化和抗胺基因生物活性.
这些NCP显示了先进的生物医学应用的巨大潜力,需要结合磁性和抗氧化功能.

关键词:

具有抗氧化剂和抗胺活性.二氧化的二氧化.磁铁的磁铁是磁性质的磁铁.磁化是一种磁化.形态学形态学形态学特定损耗功率的功率损失.综合合成是一种合成.核心/外纳米复合材料

更多相关视频

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Stable Aqueous Suspensions of Manganese Ferrite Clusters with Tunable Nanoscale Dimension and Composition

Stable Aqueous Suspensions of Manganese Ferrite Clusters with Tunable Nanoscale Dimension and Composition

Published on: February 5, 2022

相关概念视频

Diamagnetic Shielding of Nuclei: Local Diamagnetic Current

Diamagnetic Shielding of Nuclei: Local Diamagnetic Current

An applied magnetic field causes the electrons present in the molecule to circulate, setting up a local diamagnetic current within the molecule. The local diamagnetic current arising from circulating sigma-bonding electrons induces a magnetic field, Blocal that opposes the applied magnetic field, B0. The effective magnetic field experienced by these nuclei is given by the difference between the applied and local magnetic fields in a phenomenon called local diamagnetic shielding. Essentially,...

Ferromagnetism

Ferromagnetism

Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...