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向可溶性环氧化酶的PROTAC激活AMPK并抑制内分泌网膜应激

Mona Peyman1, Emma Barroso1, Andreea L Turcu2

  • 1Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028 Barcelona, Spain; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-Instituto de Salud Carlos III, 28029 Madrid, Spain; Pediatric Research Institute-Hospital Sant Joan de Déu, 08950 Esplugues de Llobregat, Spain.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|October 12, 2023
PubMed
概括

一种名为ALT-PG2的新型蛋白质分解向化成体 (PROTAC) 有效地降解可溶性环氧化酶 (sEH) 蛋白质. 这种降解会激活AMP激活蛋白激酶 (AMPK),并减少内分泌网膜应激和炎症.

关键词:
这就是AMPKK.压力ERER压力ERER压力肝细胞 肝细胞这就是PROTAC.在 SEHH SEH 中.

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