核桃消费和肠道微生物代谢:来自随机,交叉,受控养研究的探索性分析结果
Kristina S Petersen1, Mansi Chandra2, Jeremy R Chen See2
1Department of Nutritional Sciences, Texas Tech University, Lubbock, TX, USA; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
Clinical nutrition (Edinburgh, Scotland)
|October 12, 2023
概括
核桃的消费会改变肠道细菌的基因表达,并可能通过GATM上调调节增加homoarginine的产量. 这表明了核桃如何降低心血管疾病风险的新机制.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 代谢途径 代谢途径
背景情况:
- 核桃对肠道微生物群功能的影响尚不清楚.
- 研究核桃丰富饮食如何影响细菌基因表达对于了解其健康益处至关重要.
研究的目的:
- 为了比较 walnut-enriched diet (WD) 与对照饮食对细菌基因表达的影响.
- 探索肠道微生物群的功能变化受到核桃消费的影响.
主要方法:
- 一项随机,交叉,受控养研究,涉及35名参与者.
- 转录基因分析用于评估三种饮食条件下的细菌基因表达:WD,没有核桃的脂肪酸匹配饮食 (WFMD) 和油酸替代饮食 (ORAD).
主要成果:
- 核桃消费显著改变了活跃表达基因的β多样性.
- 在WD之后,观察到代谢相关基因的表达增加,包括糖氨酸胺转移酶 (GATM).
- 戈多尼菌活性和GATM基因表达的特定增加与核桃摄入有关.
结论:
- 核桃的摄入量可以通过肠道微生物群调节来增强内源性homoarginine生产.
- 肠道细菌对GATM的升级代表了核桃对心血管潜在益处的新途径.
- 由于研究的探索性质,需要进行进一步的研究来证实这些发现.
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