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室内颗粒物诱导伴侣亚托皮狗的表观遗传变化

Jihyun Kim¹, Yeji Kim¹, Yunji Song¹

¹Department of Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, South Korea; BK 21 project team, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, South Korea.

Ecotoxicology and environmental safety

|October 12, 2023

概括

高室内空气污染,特别是颗粒物 (PM),与狗的亚托皮炎 (AD) 有关. 暴露可能导致表观遗传变化,特别是关键基因中的DNA甲基化,导致AD发展.

科学领域:

环境健康环境健康
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
兽医皮肤病学兽医皮肤病学

背景情况:

亚托皮炎 (AD) 的患病率正在上升,室内空气污染物 (IAP) 被怀疑是贡献者.
颗粒物 (PM) 和挥发性有机化合物 (VOC) 是已知会影响DNA甲基化 (DNAm) 等表观遗传标记的IAP.
由于高PM暴露,DNAm在AD病变发生中的特定作用仍然不清楚.

研究的目的:

通过DNAm. 调查IAP暴露对AD发展和表观遗传变化的影响.
用伴侣狗与主人共享室内环境作为模型.
探索特定的IAP和DNAm在犬类AD中的关联.

主要方法:

狗被分为AD (n=47) 和对照 (n=21) 组.
在48小时内测量了家庭IAP度 (PM2.5,PM10,VOC).
在选择的狗身上进行了DNAm分析,并进行了临床和免疫学评估.

主要成果:

抗炎症组的PM2.5,PM10和VOC度显著更高.
在AD组的LDLRAD4,KHSRP和CTDSP2基因中观察到显著的DNAm差异,与PM10暴露相关.
基因甲基化水平与蛋白质生产相关,将表观遗传变化与AD联系起来.

结论:

高室内PM暴露可以通过甲基化LDLRAD4,KHSRP和CTDSP2.2在狗中表观遗传驱动AD的发展.
改善室内环境对于预防AD至关重要,与"One Health"概念保持一致.
伴侣狗是了解人类环境健康影响的宝贵典范.

关键词:

亚托邦性皮肤炎 (Atopic Dermatitis) 是一种不良的疾病.狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.室内室内活动甲基化甲基化甲基化颗粒物质颗粒物质是什么

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