艾滋病毒和真菌优先病原体
Hatim Sati1, Ana Alastruey-Izquierdo2, John Perfect3
1Antimicrobial Resistance Division, WHO, Geneva, Switzerland.
The lancet. HIV
|October 12, 2023
概括
四种机会性真菌病原体导致艾滋病毒晚期感染者的严重疾病和死亡. 世界卫生组织 世界卫生组织
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 侵袭性真菌感染 (IFI) 构成重大威胁,尤其对艾滋病毒发病的患者来说.
- 机会性真菌病原体是这一群体中发病和死亡的主要原因.
- 全球卫生倡议越来越多地关注真菌病.
研究的目的:
- 突出四种特定的机会性真菌病原体在与艾滋病毒相关的IFI中发挥的关键作用.
- 强调这些病原体对全球健康的影响,特别是在低收入和中等收入国家.
- 倡导改善诊断,监测和公共卫生战略.
主要方法:
- 世界卫生组织的真菌优先病原体清单 (FPPL) 的审查.
- 在FPPL中列出的真菌病原体的识别,这些真菌病原体是艾滋病毒晚期感染者中IFI的重要原因.
- 对这些病原体的流行病学影响和地理分布的分析.
主要成果:
- 世卫组织FPPL确定了19种优先的真菌病原体.
- 四种病原体Cryptococcus neoformans,Histoplasma spp.,Pneumocystis jirovecii和Talaromyces marneffei对与艾滋病毒相关的IFI特别重要.
- 这四种病原体不成比例地影响着低收入和中等收入国家的个人.
结论:
- 新型菌 (Cryptococcus neoformans),Histoplasma spp.,Pneumocystis jirovecii和Talaromyces marneffei是艾滋病毒晚期感染者面临的重大威胁.
- 迫切需要加强诊断,监测,创新支持和公共卫生干预措施.
- 解决这些真菌感染对于减少与艾滋病毒相关的死亡率至关重要.
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