特定于SARS-CoV-2的T调节性淋巴细胞显示功能可塑性增加
Laura Esparcia-Pinedo1, Ángel Lancho-Sánchez1, Ilya Tsukalov2
1Immunology Department, Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain.
Clinical immunology (Orlando, Fla.)
|October 12, 2023
概括
称为T调节性 (Treg) 淋巴细胞的免疫细胞在对SARS-CoV-2的反应中显示了CCR9和CCR6表达的增加. 这表明这些适应性细胞在COVID-19严重程度和自身免疫性疾病中起着作用.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 病变的发生和发病.
背景情况:
- 了解SARS-CoV-2感染中的免疫细胞作用对于COVID-19的病原和疾病变异性至关重要.
- 在T淋巴细胞上基因受体表达会影响免疫反应和疾病的结果.
研究的目的:
- 分析SARS-CoV-2特异性CD4+T淋巴细胞上的化学因受体表达 (CCR9,CCR6).
- 研究COVID-19和接种疫苗的个体中调节性T细胞 (Tregs) 的功能特征和异质性.
主要方法:
- 对CD4+T细胞上的化学因受体表达的流动细胞计分析.
- 评估细胞因子的产生 (IL-10,IL-17) 和转录因子的表达 (FoxP3,Notch4).
- 在接种疫苗的捐赠者,康复者和COVID-19患者中比较免疫细胞概况.
主要成果:
- 在接种疫苗的人和COVID-19患者中观察到CCR9+和CCR6+CD4+T细胞的增加.
- CCR9+ CD4+ T细胞富含具有异质调节活性的调节性T细胞 (Tregs).
- 在重症COVID-19患者中,CCR6+ Tregs显著增加,这表明肺损伤的作用.
结论:
- 一个特定于SARS-CoV-2的Treg群体表现出增强的可塑性,有助于各种疾病反应.
- 这种Treg可塑性可能是COVID-19差异性致病的基础,以及感染后自身免疫性疾病的发展.
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