卡贝戈林与皮里多克素对抑制哺乳的有效性 - 一项随机对照试验
Adi Dayan-Schwartz1, Enav Yefet2, Manal Massalha1
1Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel; Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
American journal of obstetrics and gynecology
|October 12, 2023
概括
卡伯戈林在抑制哺乳期方面比皮里多克辛更有效,尽管副作用较轻微. 对于那些对卡伯戈林有禁忌的女性来说,激素仍然是一个可行的选择.
科学领域:
- 生殖医学 生殖医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于各种原因,可以寻求抑制哺乳期.
- 卡伯戈林是一种常见的用于抑制哺乳的药物,但具有禁忌和不良影响.
- 铁素 (维生素B6) 是一种具有良好的安全性特征的替代品.
研究的目的:
- 为了比较cabergoline与pyridoxine在产后患者的乳房抑制方面的疗效.
主要方法:
- 一项随机对照试验,涉及产后患者寻求抑制哺乳期.
- 患者接受了卡伯戈林或皮里多克辛.
- 哺乳抑制的成功被定义为在第7天完全没有充血和疼痛.
- 其次结果包括牛奶泄漏,不良反应,发烧和乳腺炎.
主要成果:
- 卡伯戈林在乳抑制方面表现出优异的效果,与皮里多克辛相比 (78%与35%的成功率相比;P<.0001).
- 在卡伯戈林组中,较少的患者经历了牛奶泄漏.
- 卡伯戈林的轻微不良反应发生率较高 (31%对9%),在两组中都没有报告重大不良事件.
- 由于治疗失败,21%的皮里多克辛患者转换为卡伯戈林.
结论:
- 卡伯戈林在抑制哺乳期方面比铁素更有效.
- 虽然卡贝戈林有更多的副作用,但它们通常是温和的.
- 对于那些不能服用卡伯戈林的患者来说,皮里多是合适的替代品.
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