大脑干对穿皮漫神经刺激的反应对心血管外流的因果影响
Nicola Toschi1, Andrea Duggento2, Riccardo Barbieri3
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome., Italy.
通过皮肤进行的耳膜迷走神经刺激 (taVNS) 能够触发脑干核,从而影响心率的变化. 这项研究揭示了使用先进的神经成像技术在人类中脑干活动和心血管外流之间的因果关系.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 自主神经系统研究 自主神经系统研究
背景情况:
- 众所周知,通过皮肤进行的耳膜迷走神经刺激 (taVNS) 可以启动调节自主功能的大脑干电路.
- 在人体中对taVNS产生异常阴道反应的确切生理机制尚不完全理解.
研究的目的:
- 开发和应用一种新的模式来估计taVNS期间的方向性脑心相互作用.
- 确定特定脑干核活动与心血管外流之间的因果关系.
主要方法:
- 采用了格兰杰因果关系方法的重构,并使用了基于变的非参数统计数据.
- 将该方法应用于接受taVNS的健康受试者的超高场 (7T) 功能磁共振成像 (fMRI) 数据.
主要成果:
- 鉴定出高灵敏度的taVNS唤起的功能性脑干反应,证实了taVNS和fMRI信号在Nucleus tractus solitarii (NTS) 之间的因果关系.
- 在大脑干核和心血管外流 (高频心率变化) 之间阐明了信息继电路.
- 证明大脑干中的关键心血管控制核因果影响人类taVNS诱导的心血管外流.
结论:
- 开发的因果关系方法使得大脑干核活动与心血管外流之间的定向相互作用的非侵入性评估成为可能.
- 这项研究为taVNS.通过taVNS.对人类大脑心脏轴调节提供了新的见解.
更多相关视频
06:31Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations
Published on: January 7, 2019
11:02Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
Published on: August 21, 2015
相关概念视频
Regulation of Heart Rates
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The Parasympathetic Nervous System
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
Pathophysiology of Cardiac Performance
