儿童早期下呼吸道症状,呼吸道过敏反应和学龄肺功能之间的联系
Anette M Määttä1, L Pekka Malmberg1, Anna S Pelkonen1
1Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
概括
幼儿早期呼吸道过敏反应 (AHR) 与以后的阻塞性肺功能和血液中异敏性有关. 这表明2型炎症,并表明可逆性气道阻塞在学龄儿童.
科学领域:
- 儿科肺病学 儿科肺病学
- 过敏和免疫学 过敏和免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 幼儿气道过敏反应 (AHR) 对学龄肺功能的影响尚不清楚.
- 调查早期的AHR对于了解儿童的长期呼吸系统健康至关重要.
研究的目的:
- 为了前性地评估幼儿早期下呼吸道症状和AHR史的学龄儿童的肺功能.
- 将这些发现与健康对照进行比较,并探索2型炎症的标志物.
主要方法:
- 一项纵向研究跟踪了3岁以下的193名有症状的儿童,在11岁时对84名儿童进行了随访.
- 测量包括亚托皮标志物,甲胆AHR和肺功能 (FEV1,FVC).
- 还评估了40名没有先前肺部疾病的儿童的对照组.
主要成果:
- 患有早期AHR的儿童表现出更高的血中乙素和更低的支气管扩展前FEV1/FVC Z-分数.
- 支气管扩展后的肺功能在AHR组之间没有显著差异.
- 幼儿时期的亚托皮与以后的肺功能和亚托皮标志物有关,但不是AHR.
结论:
- 在有症状的幼儿中增加的AHR与随后的阻塞性肺功能有关.
- 这种阻塞在支气管扩张后似乎是可逆的,并且与血液中异敏性有关,这表明2型炎症.
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