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通过共同结晶化策略改善olaparib的物理化学和药理动力学特性

Xia-Lin Dai1, Bo-Wen Pang1, Wen-Ting Lv1

  • 1School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China.

International journal of pharmaceutics
|October 12, 2023
PubMed
概括

卵巢癌的PARP抑制剂Olaparib (OLA) 的口服吸收性很差. 与有机酸共同结晶显著改善了OLA.

关键词:
在Cocrystal中使用.双碳酸二氧化碳酸是什么这就是Olaparib.药物动力学 药物动力学可溶性 溶解度 可溶性 溶解度

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