探索β-葡萄糖作为一种微纳米系统,用于口服,准结肠
Qing-Qing Dong1, Qian Wu2, Yi Lu2
1Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, PR China; Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, PR China.
International journal of biological macromolecules
|October 12, 2023
概括
作为一种天然的多糖体,β-葡萄糖对开发先进的口腔结肠特异性输送系统 (OCDDS) 有前途. 这些系统增强药物稳定性和治疗结肠输送的治疗效果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 口服结肠特异性输送系统 (OCDDS) 对于向结肠和直肠向药物输送至关重要.
- 微/纳米结构的OCDDS增强药物稳定性,生物可用性和保留时间,改善治疗结果.
- 设计OCDDS的挑战包括pH值变化,酶降解和系统代谢.
研究的目的:
- 审查可生物降解的天然多糖,特别是β-葡萄糖,对于微/纳米 OCDDS 的潜力.
- 探索基于β-葡萄糖的OCDDS的化学结构,益处和应用.
- 确定在结肠特异性药物输送中使用β-葡萄糖的缺点和未来机会.
主要方法:
- 关于β-葡萄糖在药物输送中的特性和应用的文献综述.
- 对β-葡萄糖的化学结构和对OCDDS的修改进行分析.
- 评估现有的基于β-葡萄糖的微/纳米 OCDDS及其性能.
主要成果:
- β-葡萄糖表现出生物相容性,易于修饰和结肠特异性降解,使其适合OCDDS.
- 已经开发了各种基于β-葡萄糖的微/纳米 OCDDS,证明了增强药物输送的潜力.
- β-葡萄糖的特殊加工特性和形状灵活性有利于微型/纳米结构的形成.
结论:
- 在微/纳米 OCDDS 设计中,β- 葡萄糖是一个有前途的自然多糖体,可以克服 OCDDS 设计的挑战.
- 基于β-葡萄糖的OCDDS提供了增强的稳定性,生物可用性和有针对性的输送到结肠.
- 进一步研究β-葡萄糖的潜力可以导致新的和有效的结肠特异性药物输送策略.
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