通过视网来向乳腺癌干细胞:治疗治疗的新希望
Nusrat Jan1, Shazia Sofi1, Hina Qayoom1
1Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar 190006, India.
Critical reviews in oncology/hematology
|October 12, 2023
概括
乳腺癌干细胞 (BCSCs) 驱动化学抵抗和复发. 这项研究回顾了BCSCs,其生物标志物和信号通路,强调了像Adapalene这样的视网类药物作为潜在的针对这些耐药细胞的疗法.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳腺癌是女性癌症死亡的主要原因,由于药物耐药性,治疗失败率高.
- 乳腺癌干细胞 (BCSCs) 是负责瘤发病,复发和化学抵抗的亚群.
- 确定新的治疗点对于克服乳腺癌治疗耐药性至关重要.
研究的目的:
- 总结关于乳腺癌干细胞 (BCSCs) 的当前知识,包括它们的生物标志物和相关的信号通路.
- 探索视网类药物的潜力,作为对抗BCSCs和化学抵抗的治疗策略.
- 突出阿达帕伦作为一个有前途的视网类药物来准BCSCs.
主要方法:
- 关于乳腺癌干细胞,生物标志物,信号通路和视网类活性研究的文献综述.
- 分析特定生物标志物 (例如CD44+,CD24-/LOW,ALDH) 在BCSC中的作用.
- 检查在BCSC中涉及的信号通路 (例如,刺,Notch,Wnt/β-catenin,JAK/STAT,PI3K/AKT/mTOR) 的研究.
主要成果:
- BCSCs具有自我更新和分化能力,有助于瘤形成和复发.
- 关键的BCSC生物标志物包括CD44+,CD24-/LOW,ALDH,CD133和CD49f.
- 信号通路的失调促进BCSCs的形成和存活,导致药物耐药性.
结论:
- 视网类药物,维生素A衍生物,通过诱导分化和亡,表现出抗癌性质.
- 视网类药物可以调节基因表达,提供针对BCSCs的潜在策略.
- 第三代视网类药物阿达巴林 (Adapalene) 是有前途的治疗药物,可以向BCSCs,克服乳腺癌中的化学抵抗.
相关概念视频
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:40Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
01:20The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
02:34Inhibition of Cdk Activity
4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K