马过敏:卷曲马可以调解免疫耐受性
Alexandra Mitlehner1, Caspar Mitlehner1, Monika Reißmann2
1Internal Medicine, Praxis, Klappholz, Germany.
Pneumologie (Stuttgart, Germany)
|October 12, 2023
概括
美国巴什克尔卷曲马可能是低过敏的. 暴露减少了骑手的过敏反应,88%的患者对其他马产生了耐受性,这表明可以诱导免疫耐受性.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 动物科学动物科学
- 皮肤病学 皮肤病学
背景情况:
- 美国巴什克尔卷曲马被认为是低过敏的.
- 支持这一说法的临床证据有限.
- 马类过敏影响了相当一部分人口.
研究的目的:
- 调查暴露于卷曲马对患有马类过敏的个体的临床影响.
- 为了确定暴露于卷曲马是否可以诱导对其他品种马的耐受性.
- 为了探索Curly Horse低过敏性背后的潜在机制.
主要方法:
- 141名过敏于马的患者接受了对马的受控暴露 (骑马,刷牙).
- 测量了肺功能 (FEV1,PEF,PNIF) 和鼻腔通透度.
- 一小部分患者每年都接受鼻腔挑测试,以评估对其他马的耐受性.
- 分析了IgE免疫血栓和IgG抗体水平.
主要成果:
- 持续接触曲马会显著降低过敏骑手的反应能力.
- 过敏事件很少发生,主要发生在前十个骑行小时内.
- 88%完成研究的患者对其他马产生了免疫耐受性.
- 在Curly和非Curly马毛之间没有发现IgE结合蛋白的差异.
- 在耐受性患者中观察到抗马 IgG 抗体水平的增加.
结论:
- 持续接触曲马可以诱导过敏个体的免疫耐受性.
- 这种耐受性扩展到其他马种.
- 减少临床过敏性的机制尚不清楚,但可能涉及阻断IgG抗体.
- 卷曲马可能为患有马类过敏的人提供治疗选择.
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