麻醉性肝脏的症状和治疗方法
Susanne Hafner1, Thomas Seufferlein2, Alexander Kleger2
1Institute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University Ulm Medical Centre, Ulm, Germany.
概括
无菌性肝是罕见的,难以诊断的,通常发生在炎症性肠道疾病中. 免疫调节疗法对于管理这些无菌并预防复发至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 麻醉性肝是罕见的,由于缺乏临床指南,这给诊断带来了挑战.
- 无菌性肝很少发生,并且经常被误诊.
研究的目的:
- 分析无菌性肝的病例报告,以了解它们的特征,诊断和管理.
- 确定无菌性肝和其他疾病之间的关联,并评估治疗结果.
主要方法:
- 系统地选MEDLINE和PUBMED数据库,从最初到2022年11月的病例报告.
- 分析患者的人口统计,症状,并发病,治疗和疾病过程.
主要成果:
- 确定了30例无菌性肝,经常涉及脏 (n=18).
- 常见的表现包括发烧,腹部疼痛和炎症标志物升高,与炎症性肠病 (n=18) 经常伴随.
- 在长期随访中观察到的高复发率 (10/14) 表明需要维持治疗.
结论:
- 在对抗生素不反应的无菌的情况下,应该怀疑无菌肝.
- 免疫调节维持疗法是有必要的,因为在患有无菌性肝的患者中,复发的风险很高.
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