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携带BRCA1/2突变的携带者和降低风险的乳房切除术:谁接受手术以及潜在的好处

Sydney M Record1, Samantha M Thomas2, Koumani Ntowe1

  • 1Department of Surgery, Duke University Medical Center, Durham, NC, USA.

American journal of surgery
|October 12, 2023
PubMed
概括

降低风险的乳腺切除术 (RRM) 是对BRCA1/2突变载体的乳腺癌预防的关键策略. 这项研究发现,RRM与改善的整体存活率有关,这表明它对这个高风险群体的重要性.

关键词:
这就是BRCA BRCA.乳腺癌 乳腺癌 乳腺癌遗传学 遗传学 是一个进行乳腺切除术.预防性 预防性 预防性降低风险 - 降低风险

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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