在完全锁定状态下,肌缩侧面硬化症患者的体感通路功能障碍
Toshio Shimizu1, Yuki Nakayama2, Kentaro Hayashi3
1Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
概括
体感唤起潜能 (SEP) 在完全锁定状态 (CLIS) 的肌缩侧面硬化症 (ALS) 患者中揭示了严重的体感通路功能障碍. 中间神经SEP不适合在这个患者群体中进行通信.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
- 患有ALS的患者可以达到完全锁定状态 (CLIS),严重限制通信选择.
- 研究感官通路的功能对于了解疾病进展和潜在的沟通辅助工具至关重要.
研究的目的:
- 在完全锁定状态 (CLIS) 的ALS患者中调查体感路径的功能,并需要侵入性通风.
- 评估中枢神经体感觉唤起潜能 (SEP) 作为CLIS ALS患者沟通方法的实用性.
主要方法:
- 中间神经的体感唤起潜力 (SEP) 在CLIS中检查了17名ALS患者.
- 评估了特定的SEP组件 (N9,N13,N20,P25) 和中央传导时间 (CCT).
- 数据与73名健康对照人进行了比较,分析了包括SOD1和FUS在内的遗传变异.
主要成果:
- 在SEP组件中存在异常:N20和N13分别在12名和10名患者中被废除.
- 在4名和3名患者中观察到N20和N13的延长延迟时间.
- 中心传导时间 (CCT) 在5名患者中延长,在2名SOD1突变患者中,N9不存在或减少. 总的来说,与对照组相比,患者的SEP显著异常.
结论:
- 在CLIS中,ALS患者中,中央体感路径显著受损.
- 中间神经的SEP不是一个可行的方法来通信在ALS患者谁已经达到一个完全锁定状态.
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