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使用NexoBridTM酶去和凝血异常的使用

Helen Capitelli-McMahon¹, Susan McCrossan¹, Jonathan Kershaw¹

¹Pinderfields General Hospital, Mid-Yorkshire Trust, Wakefield, UK.

Burns : journal of the International Society for Burn Injuries

|October 12, 2023

概括

使用梅林 (NexoBridTM) 的酶解 (ED) 与标准手术护理相比,在大型烧伤 (>15% TBSA) 中不会显著扰乱患者的凝血. 这项研究没有找到令人信服的证据表明ED会导致凝血异常,支持其在广泛的烧伤治疗中使用.

科学领域:

烧伤护理和治疗方法
伤口愈合和组织再生.
外科手术和干预程序.

背景情况:

有限的证据存在于基于烯的酶体脱bridement (NexoBridTM) 和其对患者凝血的影响.
对凝血异常的担忧导致人们不愿意在较大的烧伤中使用酶解脱剂 (ED).
这项研究解决了对ED对严重烧伤病例凝血影响的更多数据的需求.

研究的目的:

在接受ED治疗的患者中,对超过15%的TBSA或需要重症监护的烧伤进行重大凝血干扰的调查.
为了比较治疗ED的患者的凝血概况与标准护理 (SOC) 手术除血.
评估ED在治疗严重烧伤方面的安全性和有效性.

主要方法:

一个单一中心的回顾性研究,从2017年到2020年治疗ED的患者.
接受ED的患者与接受SOC的患者根据年龄,TBSA烧伤百分比和吸入伤害进行匹配.
在除菌前和后监测凝血概况 (PT,aPTT,血小板计数).

主要成果:

在ED和SOC组之间没有观察到前列血时间,激活的部分血栓形成时间或血小板计数的统计学上显著差异.
在手术后的两组中都注意到凝血参数的轻微,无意义的偏差.
该研究包括26名治疗ED的患者和匹配的对照组.

结论:

与大型烧伤患者的标准手术脱bridement相比,酶脱bridement (ED) 似乎不会导致显著的凝血异常.
研究结果表明,对凝血的担忧不应阻止ED用于深度部分厚度和全厚度烧伤.
这项研究为有限的文献做出了贡献,表明ED是广泛燃烧管理的可行选择.

关键词:

布罗梅林是一种不质的蛋白质.凝血病是一种凝血病.酶性脱bridement 是一种酶性脱bridement 的方法.重症监护室的重症监护室是重症监护室的重症监护室.这就是NexobridTM.

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