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通过TRIM24介导的STAT6乙化抑制了Th2诱导的过敏性鼻炎

Liyan Yue¹, Qiaojing Jia¹, Jinhui Dong²

¹ENT Department 1, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Allergy, asthma & immunology research

|October 12, 2023

概括

含有三部分基因的24 (TRIM24) 通过调节信号传感器和转录6 (STAT6) 乙化激活剂来抑制过敏性鼻炎 (AR). 在AR患者中,较低的TRIM24表达与疾病严重程度的增加相关.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
过敏研究研究过敏

背景情况:

过敏性鼻炎 (AR) 是一种T助手2型 (Th2) 介导的炎症性疾病.
E3结合酶TRIM24影响STAT6的乙化,影响其活性.
TRIM24在AR病变发生中的特定作用需要进一步阐明.

研究的目的:

在过敏性鼻炎的背景下研究TRIM24的功能.
探索TRIM24影响AR中的Th2介导炎症的分子机制.

主要方法:

从AR患者的外周血液单核细胞 (PBMC) 和CD4+T细胞中测量TRIM24表达.
产生的TRIM24条件淘汰赛小鼠,缺乏CD4+T细胞.
在野生类型和淘汰赛小鼠中评估了AR症状,IL-4水平,CD4+T细胞增殖,激活,极化和STAT6活性.

主要成果:

在AR患者的PBMC和CD4+T细胞中,TRIM24表达被下调.
缺乏TRIM24的小鼠表现出加剧的AR症状和增加的IL-4产量.
由于STAT6乙化减少,TRIM24缺乏导致Th2极化增强和STAT6活性增加.

结论:

TRIM24在Th2介导的过敏性鼻炎中起抑制作用.
TRIM24通过调节STAT6乙化和活性来调节AR.
TRIM24的功能与其N端RIGN域和STAT6 Lys383乙化位点有关.

关键词:

在STAT6中,我们可以使用STAT6.在T细胞,T细胞.在 TRIM24 中,Th2 Th2 的意思是什么?通过乙化处理.过敏性鼻炎过敏性鼻炎转录因子的转录因子

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