在极地海洋中巨型病毒的基因组适应
Lingjie Meng1, Tom O Delmont2,3, Morgan Gaïa2,3
1Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, 611-0011, Japan.
Nature communications
|October 12, 2023
概括
极地海洋中的巨型病毒通过改变它们的基因功能来适应寒冷,这种策略与它们的宿主不同. 这种病毒对寒冷环境的适应在整个进化过程中反复发生.
科学领域:
- 海洋病毒学 海洋病毒学
- 欧核生物病毒 欧核生物病毒
- 基因组学和生物信息学
背景情况:
- 极地海洋拥有独特的生物多样性,尽管极度寒冷.
- 极地生态系统中的病毒适应策略在很大程度上仍未被探索.
- 大型和巨型DNA病毒 (Nucleocytoviricota,Mirusviricota) 具有不同的功能基因.
研究的目的:
- 调查大型和巨型病毒的全球生物地理和功能基因谱.
- 了解极地海洋环境中的病毒适应机制.
- 比较病毒和宿主适应寒冷的策略.
主要方法:
- 利用全球海洋真核病毒数据库进行分析.
- 应用生物地理分析以确定病毒社区的分离.
- 采用祖先的利基重建来推断进化适应.
- 分析了与极性适应相关的病毒基因含量.
主要成果:
- 证实了分离极地和非极地病毒群体的明显生态屏障.
- 在极地与非极地边界的病毒宿主网络中,证明了温度驱动的变化.
- 显示病毒在它们的基因组中反复,独立地适应极地条件.
- 确定了许多与极地适应相关的病毒基因,与宿主适应不同.
结论:
- 巨型病毒通过修改它们的功能基因库来适应寒冷的极地环境.
- 寒冷海洋中的病毒适应策略与它们的真核宿主不同.
- 病毒中极性适应的进化途径是多样化和反复的.
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