临床上相关的人类疟疾寄生虫无法通过蚊子传播
Victoria A Balta1,2, Deborah Stiffler1,2, Abeer Sayeed1,2
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Nature communications
|October 12, 2023
概括
疟疾寄生虫 (Plasmodium falciparum) 的阿托瓦昆耐药性显著损害了它们在蚊子中的发展和传播. 昆虫载体的这种严重的健康成本大大降低了耐药疟疾在野外传播的风险.
科学领域:
- 疟疾学 疟疾学
- 寄生虫学的寄生虫学
- 药物耐药性研究 药物耐药性研究
背景情况:
- 长效注射抗疟药物,如阿托瓦,有可能成为疟疾的"化学疫苗".
- 人们对耐药疟疾寄生虫的选择和传播存在担忧.
- 之前的实验室研究表明,阿托瓦昆耐药性降低了蚊子中的寄生虫适应性,但对菌菌的临床数据缺乏.
研究的目的:
- 调查蚊子中临床相关的抗阿托瓦奎抗性Plasmodium falciparum菌株的适应性和传播.
- 评估一种特定的阿托瓦抗性突变 (B细胞染色体中的Y268S) 对寄生虫发育和传染性的影响.
主要方法:
- 产生抗阿托瓦昆抗性的Plasmodium falciparum寄生虫,其中细胞染色体b的Y268S突变.
- 对抗性 (Y268S) 与野生类型寄生虫在Anopheles stephensi和An.的发展和适应性的比较分析. 冈比亚的蚊子. 冈比亚的蚊子.
- 从蚊子向人性化小鼠模型的寄生虫传播的评估.
主要成果:
- 与人类atovaquone治疗失败相关的Y268S突变导致蚊子内寄生虫发育的重大缺陷.
- 耐药性寄生虫的表现是减少了游戏细胞的鞭,卵囊变小,并没有杂虫.
- Y268S突变未能从蚊子传播到人性化小鼠,这表明严重的健康成本.
结论:
- 临床上相关的阿托瓦昆耐药性对蚊子载体中的Plasmodium falciparum寄生虫施加了相当大的健康负担.
- 这种健身成本显著降低了在现场传播抗阿托瓦昆抗性疟疾寄生虫的可能性.
- 这些发现支持继续开发基于atovaquone的抗疟疾策略,因为耐药性可能在环境中自我限制.
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