通过综合生物信息学对产前中lncRNA介导的ceRNA调节网络的表征
Liping Zhu1, Chengfeng Liu1, Yongmei Xu1
1Department of Obstetrics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, No. 26 Daoqian Street, Gusu District, Suzhou, 215000, Jiangsu, China.
Scientific reports
|October 12, 2023
概括
这项研究揭示了长非编码RNAs (lncRNAs) 和竞争的RNA网络参与了孕前 (PE) 病原发生. 了解这些lncRNA角色为PE发展和潜在的治疗点提供了新的见解.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 产科 产科 产科 产科 产科
背景情况:
- 孕前 (PE) 对母亲和婴儿的健康构成重大风险.
- 对于PE的根本原因 (病原性) 尚不完全了解.
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在复杂疾病中的调节作用.
研究的目的:
- 研究lncRNAs和竞争性内源RNA (ceRNA) 网络在PE病变发生过程中的参与.
- 与健康的孕妇 (HPW) 相比,分析PE患者的lncRNA表达模式.
- 使用生物信息学构建 lncRNA 中介的 ceRNA 调节网络.
主要方法:
- 在PE和HPW组之间对lncRNAs的差异表达分析.
- 生物信息分析以确定丰富的分子功能和KEGG通路.
- 基于ceRNA得分的lncRNA-miRNA-mRNAceRNA网络的构建.
主要成果:
- 在PE中鉴定出896个差异表达的lncRNA (586个上调,310个下调).
- 丰富的分子功能包括脂和脂代谢.
- 构建了两个不同的ceRNA网络,涉及许多lncRNA,miRNA和mRNA.
结论:
- lncRNAs和ceRNA网络在产前的病原发生过程中发挥着至关重要的作用.
- 已识别的lncRNAs和途径为了解PE提供了潜在的目标.
- 对这些监管网络的进一步研究可能会阐明PE机制.
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